Long lasting vitamin D deficiency might result in the development of more colon tumors.
According to a research, vitamin D, specifically its receptor (VDR), play important role in slowing down the action of a key protein in the transformation process of colon cancer cells. Researchers at the Vall d`Hebron Institute of Oncology (VHIO) associated with the Alberto Sols Institute of Biomedical Research (CSIC-UAB) for the study. This protein, known as beta-catenin, normally found in intestinal epithelial cells where it helps in their grouping, is produced in large quantities when the tumor transformation begins.
Because of this, the protein remains in the cell nucleus, where it helps the cancer growing process, at this point at which vitamin D, or rather, the vitamin D receptor (VDR) works to prevent it from getting worse.
Hector Palmer, the coordinator of the study and head of the VHIO’s Stem Cells and Cancer laboratory said that,
“Our study has confirmed the pivotal role of the VDR in controlling the anomalous signal that sparks off the growth and uncontrolled proliferation of colon cells which, in the final instance, ends up causing a tumour to emerge,”
he further mentioned that,
“The stimulation of this receptor suppresses the action of the beta-catenin protein, intercepting the series of events that change the intestinal cell into a malignant tumour cell,”
The researchers examined the effect of the VDR on human colon cancer cell cultures and observed that the concentration of the changed protein, beta-catenin, increased in cells without the VDR. Hence it might be claimed that, chronic vitamin D deficiency might result in the development of more dangerous colon tumours.
According to a research, vitamin D, specifically its receptor (VDR), play important role in slowing down the action of a key protein in the transformation process of colon cancer cells. Researchers at the Vall d`Hebron Institute of Oncology (VHIO) associated with the Alberto Sols Institute of Biomedical Research (CSIC-UAB) for the study. This protein, known as beta-catenin, normally found in intestinal epithelial cells where it helps in their grouping, is produced in large quantities when the tumor transformation begins.
Because of this, the protein remains in the cell nucleus, where it helps the cancer growing process, at this point at which vitamin D, or rather, the vitamin D receptor (VDR) works to prevent it from getting worse.
Hector Palmer, the coordinator of the study and head of the VHIO’s Stem Cells and Cancer laboratory said that,
“Our study has confirmed the pivotal role of the VDR in controlling the anomalous signal that sparks off the growth and uncontrolled proliferation of colon cells which, in the final instance, ends up causing a tumour to emerge,”
he further mentioned that,
“The stimulation of this receptor suppresses the action of the beta-catenin protein, intercepting the series of events that change the intestinal cell into a malignant tumour cell,”
The researchers examined the effect of the VDR on human colon cancer cell cultures and observed that the concentration of the changed protein, beta-catenin, increased in cells without the VDR. Hence it might be claimed that, chronic vitamin D deficiency might result in the development of more dangerous colon tumours.
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